Complexation of alkyl groups and ghrelin in a deep, water-soluble cavitand.
نویسندگان
چکیده
A cavitand with ionic, but nonionizable "feet" folds around hydrophobic guests in D2O. Short alkanes and ibuprofen are included and exchange rates are slow on the NMR timescale. Normal octanoyl groups show good affinity for the cavitand and the gastric peptide ghrelin is bound at low pH and physiological temperature.
منابع مشابه
Folded alkyl chains in water-soluble capsules and cavitands.
A deep cavitand with ionic "feet" dimerizes around hydrophobic compounds in D2O. Longer n-alkane guests, C14-C18, are encapsulated in contorted conformations and NMR is used to deduce their shapes. Competition experiments establish the driving forces involved and how they compensate for the steric clashes in the folded structures of the encapsulated alkanes. Bolaamphiphiles instead prefer to bi...
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عنوان ژورنال:
- Chemical communications
دوره 50 38 شماره
صفحات -
تاریخ انتشار 2014